A Novel Mix of Polyphenols and Micronutrients Reduces Adipogenesis and Promotes White Adipose Tissue Browning via UCP1 Expression and AMPK Activation Source https://www.mdpi.com/2073-4409/12/5/714 ABSTRACT Background: Obesity is a pandemic disease characterized...
Source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516926/ ABSTRACT The present study uncovered some important and interesting aspects of the genetic and molecular pathways involved in chronic stress–induced depression-like behavior. The authors demonstrated...
The Protective Effect of a Unique Mix of Polyphenols and Micronutrients against Neurodegeneration Induced by an In Vitro Model of Parkinson’s Disease Source https://www.mdpi.com/1422-0067/23/6/3110 ABSTRACT Parkinson’s disease (PD) is second-most common...
Protective Role of Combined Polyphenols and Micronutrients against Influenza A Virus and SARS-CoV-2 Infection In Vitro Source https://pubmed.ncbi.nlm.nih.gov/34829949/ ABSTRACT Polyphenols have been widely studied for their antiviral effect against respiratory virus...
Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood Source https://pubmed.ncbi.nlm.nih.gov/34328346/ ABSTRACT Our study provides novel evidence that young adult women with...
Targeting sirtuins for the treatment of diabetes Source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110209/ ABSTRACT The data on sirtuins and their antidiabetic potential are compelling, and on-going studies will determine whether sirtuin activators will be an...
The brain, sirtuins, and ageing (Nature Reviews Neuroscience) Source https://www.nature.com/articles/nrn.2017.42 ABSTRACT In mammals, recent studies have demonstrated that the brain, the hypothalamus in particular, is a key bidirectional integrator of humoral and...
Sirtuin 1 and Alzheimer’s disease Source https://pubmed.ncbi.nlm.nih.gov/30007474/ ABSTRACT Sirtuins are NAD+-dependent enzymes that regulate a large number of cellular pathways and are related to aging and age-associated diseases. In recent years, the role of...
The Critical Role of SIRT1 in Parkinson’s Disease: Mechanism and Therapeutic Considerations Source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673849/ ABSTRACT Silence information regulator 1 (SIRT1), a member of the sirtuin family, targets histones and many...
